Cystatin SN can strongly predict chronic rhinosinusitis with nasal polyps: Study
China: Cystatin SN can help in the management of patients with chronic rhinosinusitis with nasal polyps (CRSwNP), finds a recent study in the Journal of Allergy and Clinical Immunology. According to the study, the levels of cystatin SN in nasal secretion have strong prognostic value and can aid medical guidance on CRSwNP.
Integrated care pathways (ICPs) can improve the management of CRSwNP patients. ICPs application requires development of endotype-based biomarkers to stratify patients. The value of markers and cytokines induced by cytokines for CRSwNP management is largely unknown.
Luo Zhang, Capital Medical University, Beijing, China, and colleagues aimed to determine the pharmacologic and prognostic value of type 2, non-type 2 cytokines, and markers associated with type 2 inflammation including CCL26, periostin, and cystatin SN, in nasal secretions for CRSwNP.
For the purpose, the researchers conducted a retrospective study in which 151 patients with CRSwNP were divided into discovery and validation phases. Using Luminex and ELISA, concentrations of cytokines, CCL26, periostin, and cystatin SN in nasal secretions were determined.
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