Gene Therapy Outperforms Cochlear Implants in Hearing and Speech Outcomes for Congenital Deafness: JAMA Study
China: Researchers have found in a new study conducted in China that children with congenital deafness who received gene therapy demonstrated more stable and rapid improvements in hearing, speech performance, speech-in-noise recognition, and music perception compared to those treated with cochlear implants.
The cohort study, recently published in JAMA Neurology, was conducted by Xiaoting Cheng and colleagues from the ENT Institute and Department of Otorhinolaryngology at the Eye and ENT Hospital, Fudan University, Shanghai. It evaluated the effectiveness of gene therapy targeting the OTOF gene compared to the current gold standard, cochlear implantation (CI), in children born with severe to profound hearing loss.
The study included 72 participants between 1 and 18 years of age who either underwent gene therapy (GT) or received cochlear implants. Of the screened 1,568 individuals, 11 children were enrolled in the GT group, while 61 received cochlear implants. All participants were matched based on duration of deafness and pre-treatment hearing and speech abilities.
The study led to the following findings:
- At the 12-month mark, both gene therapy (GT) and cochlear implant (CI) groups showed similar levels of hearing and speech performance.
- GT patients showed faster recovery and earlier improvements compared to the CI group.
- At 6 months post-treatment, GT patients had higher median scores on the Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS) (31.0 vs 23.5).
- By 12 months, GT patients continued to outperform CI patients on the IT-MAIS, with median scores of 32.0 vs 28.0.
- Auditory brainstem responses in GT patients showed significant improvement, with nine individuals’ hearing thresholds improving from above 95 dB to an average of 54.8 dB.
- Mismatch negativity (MMN) testing indicated faster auditory information processing in GT patients at both 6 and 12 months.
- In bimodal therapy patients (GT in one ear, CI in the other), GT outperformed CI in recognizing speech in noisy environments at 12 months.
- Bimodal therapy patients also showed better in-tune singing rates than those with bilateral cochlear implants.
- MMN latencies were shorter in bimodal therapy patients compared to those with bilateral cochlear implants, indicating faster neural processing.
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