IV desmopressin may reduce bleeding, enhance vision for surgeon during endoscopic sinus surgery
According to recent research, it has been observed that intravenous Desmopressin (DDAVP) can reduce bleeding during surgery and offer an enhanced vision for surgeon during surgery.
The study is published in the American Journal of Otolaryngology.
DDAVP causes the release of von Willebrand's antigen from the platelets and the cells that line the blood vessels where it is stored. Von Willebrand's antigen is the protein that carries factor VIII. This increase in von Willebrand's antigen and factor VIII helps to stop bleeding. Bleeding during functional endoscopic sinus surgery has always been a challenge for the quality of surgical field for surgeons. There are very few studies in the literature which state the effect of desmopressin during endoscopic surgeries especially in patients with chronic rhinosinusitis.
Hence, Fatemeh Hajimohamadi and colleagues from the Anesthesiology Research Center, Tehran University of Medical Sciences, Tehran, Iran carried out the present study to determine whether Desmopressin (DDAVP) can alter bleeding and improves surgeon visual field and decrease operation time or lessen use of anesthesiology medication in a clinical trial study.
The authors conducted this randomized clinical trial using the permuted block randomization method. The authors assessed a total of 44 patients, all of whom were enrolled in study and divided into two equal intervention-control groups.
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