No benefit of high dose amoxicillin with clavulanate for acute sinusitis, Finds study
Researchers have recently found out that adults treated for clinically diagnosed acute sinusitis did not appear to benefit from taking high-dose compared with standard-dose amoxicillin plus clavulanate.
The study is published in the JAMA Open Network.
Acute bacterial sinusitis is common, but currently recommended antibiotic treatment provides minimal benefit.
Hence, Jennifer Gregory and colleagues from the Department of Medicine and Pediatrics, Albany Medical Center Hospital, Cohoes, New York conducted the present study to confirm the previous finding that high-dose amoxicillin plus clavulanate (with double the amount of amoxicillin) may be superior to standard-dose amoxicillin plus clavulanate in adults.
The authors carried out this double-blind, comparative-effectiveness randomized clinical trial on participants included adults aged 18 years or older who were prescribed amoxicillin plus clavulanate for acute bacterial sinusitis. At an unplanned interim analysis prompted by COVID-19 restrictions, 157 of a projected 240 participants had been enrolled (mean age, 48.5 [range, 18.7-84.0] years; 117 women [74.5%]), with 79 randomized to the standard dose and 78 to the high dose; 9 and 12, respectively, withdrew or were lost to follow-up before the assessment of the primary outcome.
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