Vitamin D deficiency linked to severity of chronic rhinosinusitis with nasal polyposi, claims research

Serum vitamin D levels were assessed in 104 individuals with uncontrolled CRSwNP who were scheduled for functional endoscopic sinus surgery after failing all forms of medication treatment. The Lund-Mackay (LM) score, total nasal polyp scores, Sinonasal Outcome Test-22 (SNOT-22), and absolute eosinophil counts were used to compare vitamin D levels across individuals.

The average age of the 104 patients that were included was 42.09 ± 13.3 years, and 63.5% of them were men. Vitamin D levels were 57.9 ± 31.2 nmol/L on average. The mean score on the SNOT-22 was 65.49 ± 21.3. The LM score was 14.48 ± 6.64 on average. The overall score for nasal polyps was 4.3 ± 2.08. Vitamin D levels did not correlate with other factors, however, they did have a negative correlation with polyp grade (r = -.264, P =.007) and LM score (r = -.210, P =.032).

Overall, patients with CRSwNP frequently have vitamin D insufficiency or inadequacy. More evidence that low vitamin D levels are linked to more severe CRSwNP was established when the study discovered a negative correlation between low blood vitamin D levels. These early results suggest that vitamin D measurement may be useful in the clinical assessment and treatment of CRSwNP. 

Source:

Magboul, N. A., Alotaibi, M., Aldokhayel, F., Almazyad, L. M., Alkwai, K., Almutawa, N., Alotaibi, M., Alyousef, M. Y., Alsaleh, S., & Alroqi, A. (2024). Association Between Serum Vitamin D Level and Uncontrolled Chronic Rhinosinusitis With Nasal Polyposis. In Ear, Nose & Throat Journal. SAGE Publications. https://doi.org/10.1177/01455613241302892