Vitamin D Deficiency may increase Risk of chronic rhinosinusitis, reports research

A new study published in the European Archives of Oto-Rhino-Laryngology revealed that serum 25(OH)D deficiency is an independent risk factor for chronic rhinosinusitis (CRS), particularly eosinophilic CRS with nasal polyps (ECRSwNP). Combining serum 25(OH)D levels with peripheral eosinophil percentages may serve as a valuable biomarker for eosinophilic CRS with nasal polyps.

It is estimated that 1–4% of the general population in the US develops nasal polyps, which are inflammatory outgrowths of sinonasal tissue. Despite being seen in a number of clinical disorders, like cancer and cystic fibrosis, nasal polyps are most commonly linked to a subtype of chronic rhinosinusitis called chronic rhinosinusitis with nasal polyps (CRSwNP). Numerous endotypes and a high incidence rate characterize chronic rhinosinusitis.

The patients with eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP and nECRSwNP, respectively) frequently have a serum 25-hydroxyvitamin D (25(OH)D) insufficiency. Thus, Jianqi Wang and colleagues carried out this investigation to investigate the association between serum 25(OH)D levels and CRS risk.

There were a total of 298 healthy controls and 275 CRS patients in this research. After propensity score matching (PSM), logistic regression was used to ascertain the association between serum 25(OH)D levels and CRS risk. A decision-tree model was used to evaluate the effectiveness of different peripheral blood indicators in differentiating between ECRSwNP and nECRSwNP.