Autoimmune gastritis the driving factor in Young women towards Gastric Cancer: JAMA

Autoimmune gastritis is another possible cause of stomach cancer. With the decreasing frequency of chronic Helicobacter pylori infection, this reason may be increasing prominence.

According to the findings of a recent research, autoantibody positivity in younger women may indicate subclinical autoimmune gastritis. The findings in young girls and the corpus subsite correspond to rising cancer incidence rates in these populations. Stronger autoimmune connections in H pylori-seronegative people indicate an autoimmune gastritis paradigm in which H pylori is no longer the driving driver.

The following study was conducted by Minkyo Song and team with the objective to see if there was a link between prediagnostic autoantibodies to gastric mucosa and the risk of developing gastric cancer (GC). The findings of this study were published in the Journal of American Medical Association.

In this cohort study, nested GC case-control analyses were performed within distinct Finnish cohorts of reproductive-age women (Finnish Maternity Cohort [FMC]; born 1938-1989) and older males (Alpha-Tocopherol, Beta-Carotene Cancer Prevention [ATBC] Study; born 1916-1939). The FMC and ATBC Studies had 529 and 457 matched pairs, respectively, with mean participant ages of 30.5 and 57.5 years and medians of 17 and 11 years from baseline to cancer diagnosis. Between August 2019 and November 2020, data analysis were carried out. Immunoassays were used to assess antiparietal cell antibodies (APCAs), anti-intrinsic factor antibodies, and anti–H pylori antibodies in baseline blood. The main outcome was autoantibody associations, which were evaluated using odds ratios (ORs) and 95 percent confidence intervals (CIs).