Oral antibiotics alone noninferior to IV followed by oral antibiotics in appendicitis patients: JAMA
Finland: Adults with uncomplicated acute appendicitis treated with oral antibiotics versus IV followed by oral antibiotics had almost equal treatment success, finds a recent study in the journal JAMA.
According to the study, treatment with 7 days of oral moxifloxacin compared with 2 days of intravenous ertapenem followed by 5 days of levofloxacin and metronidazole resulted in treatment success rates greater than 65% in both groups. However, it failed to demonstrate noninferiority for treatment success of oral antibiotics compared with intravenous followed by oral antibiotics.
In patients with uncomplicated acute appendicitis, antibiotics are an safe and effective alternative to appendectomy for the management of the condition, but the optimal antibiotic regimen is not known. Considering the same, Suvi Sippola, Turku University Hospital, Turku, Finland, and colleagues aimed to compare oral antibiotics with combined intravenous followed by oral antibiotics in the management of computed tomography–confirmed uncomplicated acute appendicitis.
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