IM progesterone improves success rate of IVF in women with low progesterone levels, reveals research

Infertile women who were candidates for IVF and had progesterone levels less than 9.2 ng/ml on the ET day were included in this concurrent open-label clinical study. These women were assigned randomly to either the intervention group or control group. In addition to 400 mg of progesterone suppository every 12 hours starting on the day of ET, the intervention group was provided 50 mg of progesterone intramuscularly once daily. Just 400 mg of progesterone suppositories were given to the control group every 12 hours. These medications were taken up until 12 weeks following the ET in the case of pregnancy.

There was a significant difference (P=0.035) between the number of women who had clinical pregnancy which was around 54 (50.0%) in the intervention group and 39 (36.8%) in the control group. There was a significant difference (P=0.042) in the number of women who had ongoing pregnancy in the intervention group (47, 43.5%) and the control group (33, 31.1%). The incidence of multiple pregnancies and abortions did not significantly differ between the two groups. The intramuscular administration of 50 mg progesterone considerably boosts the clinical and continuing pregnancy rates. Overall, this study suggests that IM injection of 50 mg progesterone increases the clinical and ongoing pregnancy outcomes.

Reference:

Ebrahimi, M., Akbari Asbagh, F., Davari Tanha, F., Amirkhanloo, F., Sahraiyan, G., Feizabad, E., & Lotfi, S. (2024). The Effect of Adding Daily 50 mg Intramuscular Progesterone to 800 mg Progesterone Suppository on The In Vitro Fertilization Success Rate in Women with Low Progesterone Levels: A Clinical Trial Study. International Journal of Fertility and Sterility, 18(Suppl 1). https://doi.org/10.22074/ijfs.2023.2008438.1506