New tiny device may Isolate harmful bacteria from body fluids

Researchers at Rochester Institute of Technology have created a tiny device that can rapidly detect harmful bacteria in blood. The new device is easy to operate and it rapidly isolates, retrieves and concentrates target bacteria from bodily fluids.This will allow health care professionals to pinpoint the cause of potentially deadly infections and fight them with drugs. The study has been published in the journal ACS Applied Materials & Interfaces.

Drug-resistant bacteria, or super-bugs, are a major public health concern. Globally, at least 700,000 people die each year as a result of drug-resistant infections, including 230,000 deaths from multidrug-resistant tuberculosis.

"The rapid identification of drug-resistant bacteria allows health care providers to prescribe the right drugs, boosting the chances of survival," said coauthor Ruo-Qian (Roger) Wang, an assistant professor in the Department of Civil and Environmental Engineering in the School of Engineering at Rutgers University-New Brunswick.

Based on a new approach, the tiny new device rapidly isolates, retrieves and concentrates target bacteria from bodily fluids. It efficiently filters particles and bacteria, capturing about 86 percent of them. The nano-device has magnetic beads of different sizes that are designed to trap, concentrate and retrieve Escherichia coli (E. coli) bacteria. The small spaces between the beads are used to isolate bacteria in the device.

The inexpensive, transparent device is easy to fabricate and operate, making it ideal for detecting disease-causing organisms in laboratory and health care settings, according to the study. The research team is working to perfect the device and plans to add multiple devices onto a small chip and explore scaling up testing in the field.

For further reference log on to:

http://dx.doi.org/10.1021/acsami.9b19311