Midazolam or Propofol - which is better in acute phase for ventilated patients with sepsis

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-05-30 03:30 GMT | Update On 2022-05-30 03:30 GMT

A recent study reported that Propofol is a better choice of sedative compared to Midazolam based on a light sedation protocol that might be associated with inappropriate sedation during the acute phase, with increased coma and delirium.

The study was an analysis of data from the dexmedetomidine for sepsis in the ICU Randomized Evaluation (DESIRE) trial. Patients were divided into propofol and midazolam groups based on continuously used drug, and sedation control between groups compared on day three. They assessed the incidence of delirium, length of ICU stay, number of ventilator‐free days within the first 28 days, and mortality after 28 days.

The results showed that both groups had similar characteristics, except for age and emergency surgery. The number of well‐controlled sedation patients in the propofol group on day three was significantly higher than that in the midazolam group. The incidence of daily coma and delirium within the initial week was different between groups and increased with midazolam administration. The number of Confusion Assessment Method for ICU‐positive patients was significantly higher in the midazolam group than in the propofol group.

Hence, it was concluded that in patients with sepsis required mechanical ventilation, sedation with midazolam based on a light sedation protocol may be associated with inappropriate sedation during the acute phase, with increased coma and delirium as compared to propofol.

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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Midazolam or Propofol - which is better in acute phase for ventilated patients with sepsis

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