Empagliflozin retains benefits in 'True' HFpEF Patients

Empagliflozin provides a wide range of benefits in patients with "true" heart failure and preserved ejection fraction (HFpEF) , meaning an LVEF of 50% or greater, EMPEROR-Preserved investigators report. The main results of the placebo-controlled trial, showed that the sodium-glucose cotransporter 2 (SGLT2) inhibitor lowers the risk of CV death/hospitalization for heart failure in patients with HFpEF.

But some commentators questioned whether EMPEROR-Preserved was truly a trial of HFpEF because it included patients with ejection fractions between 41% and 49%—considered "midrange" or "mildly reduced" in practice guidelines.