Barcitinib effective in severe nail lichen planus-1st case report

A woman in her 60s presented with 1 year history of a severe nail dystrophy of all fingers of both hands. Onychomycosis was ruled out by direct examination as well as results of a culture of nail specimens. Presence of longitudinal ridging and fissuring, distal splitting, and trachyonychia led to a clinical diagnosis of severe NLP. No other cutaneous mucosal involvement was seen in the patient. Patient's NLP had been treated with 5 intramuscular triamcinolone injections (40mg per month) followed by oral acitretin (25mg, daily) for 5months without any improvement. Later methotrexate was administered to the patient which showed some efficacy but was discontinued because of adverse effects, such as fatigue and a lowering of her work capacity. The authors then began treatment with baricitinib 4mg daily which led to substantial improvement in 2months and complete clearance at 6 months.

For more details, check out the full story on the link below:

Barcitinib effective in severe nail lichen planus- 1st case report