Combination of oral ketotifen, famotidine with sunscreen benefits in melasma
A recent study showed that a combo of sunscreen plus oral ketotifen with famotidine improved facial melasma more than the use of sunscreen alone at 60 days. The study appears in the Journal of the European Academy of Dermatology and Venereology.
Ketotifen decreases the release of bioactive mediators, such as leukotrienes, histamine, and proteases. It has been suggested as a treatment for photoaging after being found to prevent mast cell deposition, degranulation, skin thickening, and wrinkles in UV irradiated hairless mice. Famotidine is an H2-receptor antagonist that suppresses histamine-mediated melanogenesis and dendricity in cultured human melanocytes, whereas H1 and H3 antagonists have no inhibitory effect.
For more details, check out the full story on link below:
Oral Ketotifen, Famotidine With Sunscreen Bests Sunscreen Alone For Treating Melasma : Study
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