Atopic dermatitis to be related to higher levels of CRP

Atopic Dermatitis (AD) is known to affect 15%-20% of children worldwide. A recent study reported that adults with atopic dermatitis (AD) are at an increased risk of developing sleep disorders -- which is associated with higher levels of the inflammatory biomarker, C-reactive protein (CRP) that might substantially increase the risk of developing adverse cardiovascular outcomes and mortality.

 The findings of the study were presented during a late-breaking abstract session at the Revolutionizing Atopic Dermatitis virtual symposium. It is associated with a significant reduction in quality of life and numerous systemic comorbidities.  To fill this knowledge gap, Varsha Parthasarathy, Johns Hopkins Department of Dermatology, Baltimore MD, and colleagues aimed to examine the comorbidity burden of sleep disorders in AD patients and associate findings with inflammatory C-reactive protein and cardiovascular comorbidities in a large, multicenter cohort.

Adverse effects of AD is clearly not known, so far its effect on sleep isn't elucidated completely. However, there is no clarity on the association between AD, sleep disturbance, and systemic inflammation.

"This elevation in CRP may contribute to the systemic inflammatory impact of AD and substantially increase the risk of cardiovascular outcomes. Physicians are recommended to screen for these sleep-related comorbidities in all AD patients." they concluded.

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CRP elevated in patients with atopic dermatitis and sleep disorders: Study