Are high insulin levels linked to increased pancreatic cancer risk, study finds
A new study from the University of British Columbia's Faculty of Medicine reveals a direct connection between high insulin levels, which are common among individuals with obesity and Type 2 diabetes, and pancreatic cancer. The research shows that excessive insulin levels can overstimulate pancreatic acinar cells, responsible for producing digestive juices, leading to inflammation that transforms these cells into precancerous cells.
This research primarily focused on pancreatic ductal adenocarcinoma (PDAC), the most common and highly aggressive form of pancreatic cancer, with a five-year survival rate of less than 10 percent. While it was already known that obesity and Type 2 diabetes increased the risk of pancreatic cancer, the precise mechanisms behind this connection remained unclear. The study highlights the role of insulin and its receptors in this process.
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