Are high insulin levels linked to increased pancreatic cancer risk, study finds

Dr. Anni Zhang, the study's first author, explained that hyperinsulinemia directly contributes to the initiation of pancreatic cancer through insulin receptors in acinar cells. This process involves the increased production of digestive enzymes, resulting in heightened pancreatic inflammation.

While insulin's role in regulating blood sugar is widely recognized, this study underscores its significance in pancreatic acinar cells. It reveals that insulin supports the physiological function of these cells in producing digestive enzymes to break down fat-rich foods. However, at elevated levels, insulin's increased activity can unintentionally foster pancreatic inflammation and the development of precancerous cells.

Reference: Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation, Cell Metabolism, DOI: 10.1016/j.cmet.2023.10.003