Genetic risk scores to help predict type 2 diabetes
The common genetic changes associated with type 2 diabetes have been extensively studied. However, it is not known whether all previous findings can be applied to people of south Asian ancestry, who are disproportionately affected yet also underrepresented in genetic studies.
according to a new study published in the open access journal PLOS Medicine, combining a genetic risk score with a clinical risk score improved the prediction of type 2 diabetes in British Pakistani and British Bangladeshi individuals, especially in the young.
Out of 338 genetic loci identified, just 76 (22.5%) were transferable to the study population of British Pakistanis and British Bangladeshis. The team then constructed a type 2 diabetes polygenic risk score for the population in the study. The tool was particularly effective in assessing risk in British Pakistani and British Bangladeshi people under the age of 40 , and also in predicting the development of type 2 diabetes after gestational diabetes.
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