Gestational Diabetes Linked to Type 2 Diabetes, but Causes Vary by Individual: Study Finds
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Women who have gestational diabetes have increased risk of type 2 diabetes in the years after delivery. Those who go on to develop the chronic disease fall into three “clusters,” each with a distinct molecular driver, according to a new study from University of Pittsburgh researchers published in Diabetes/Metabolism Research and Reviews.
These clusters point to targets for potential precision-medicine approaches for type 2 diabetes.
The team focused on 225 women who had a history of gestational diabetes and then developed type 2 diabetes within 12 years of delivery. The researchers used blood samples that had been gathered periodically as the women progressed to the chronic disease, applying computational modeling and machine learning to metabolomic, proteomic and genomic data, as well as clinical measures such as triglycerides, insulin and glucose levels.
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