Increased levels of blood caffeine might curb body fat amount and type 2 diabetes risk: Study
A high blood caffeine level might curb the amount of body fat a person carries and their risk of type 2 diabetes, suggests research published in the open access journal BMJ Medicine. The researchers used Mendelian randomisation to find out what effect higher blood caffeine levels have on body fat and the long term risks of type 2 diabetes and major cardiovascular diseases-coronary artery disease, stroke, heart failure, and irregular heart rhythm (atrial fibrillation).
The researchers looked at the role of two common genetic variants of the CYP1A2 and AHR genes in nearly 10,000 people of predominantly European ancestry, who were taking part in 6 long term studies. The CYP1A2 and AHR genes are associated with the speed of caffeine metabolism in the body.
People who carry genetic variants associated with slower caffeine metabolism drink, on average, less coffee, yet have higher levels of caffeine in their blood than people who metabolise it quickly to reach or retain the levels required for its stimulant effects.
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