Modified Insulin with On-Off Switch May Prevent Sudden Hypoglycemic Episodes in Diabetics: Study Finds
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Modified insulin that can prevent sudden drops in blood sugar has been demonstrated in laboratory experiments and animal models, reports a paper in Nature. This could provide a more flexible way to supplement insulin for individuals with diabetes and reduce sudden drops in blood glucose.
Researcher Rita Slaaby and colleagues present a modified form of insulin with activity that varies according to glucose levels in the blood. The molecule, named NNC2215, is equipped with a switch that can open and close in response to glucose. Under high glucose concentrations, the switch opens, and the insulin becomes more active, removing glucose from the blood. When glucose levels decrease, the switch moves to a closed state, which prevents glucose uptake.
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