Prevalence of Hypogonadism in Newly Onset Type 2 Diabetes Mellitus?- A Cross-sectional Study

Several cross-sectional studies worldwide have reported a high prevalence (20– 64%) of hypogonadism among males with diabetes mellitus. Association between hypogonadism and DM has recently been drawing public health attention. Hypogonadism (low testosterone) has been classically linked with sexual dysfunction. But recent data show that it is also linked with insulin resistance (IR), obesity, metabolic syndrome (MS), incident DM, dyslipidemia, cardiovascular disease, depression, and poor quality of life.

Despite all these, few studies on hypogonadism in newly onset DM are done from the Eastern part of India. So, the authors carried out a cross-sectional study to know the magnitude of the problem and predictor of hypogonadism in this part of India as ethnicity and lifestyle vary from region to region.

A total of 231 consecutive newly diagnosed males with type 2 DM were enrolled. Patients were stratified into group A (hypogonadal) and group B (eugonadal) based on TT level. Mean value of age, body mass index (BMI), A1c, waist circumference (WC), TC, TG, LDL, high-density lipoprotein (HDL), systolic blood pressure (SBP), diastolic blood pressure (DBP), uric acid (UA), and glomerular filtration rate (eGFR) in group A and group B were compared. It was found that the prevalence of hypogonadism was 38.53%.

Hence, it was concluded that the prevalence of hypogonadism is high in newly diagnosed DM. BMI, central obesity and triglyceride levels are significantly associated with low Testosterone. So obese and hyper- triglyceride patients should be evaluated for Testosterone levels at the time of diagnosis. These patients should be treated with drugs that promote weight loss, reduce insulin resistance, and raise Testosterone levels.

Reference:

Shailendra Kumar Singh, Rina Singh , Santosh Kumar Singh, Pradeep Kumar Rai. Prevalence and Predictor of Hypogonadism in Newly Onset Type 2 Diabetes Mellitus: A Cross-sectional Study. JAPI 2022; Vol 70.