Safety and Efficacy of Vildagliptin 100mg SR- Ft. Prof. Dr Aravinda Jagadeesha

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-12-15 05:47 GMT | Update On 2023-05-03 07:27 GMT

Among the gliptins, vildagliptin is the only therapy requiring twice-daily dosing and thus adversely impacts patient adherence. To reduce dosing frequency, a once-daily sustained-release (SR) vildagliptin 100 mg tablet formulation was developed with the potential to furnish comparable dipeptidyl peptidase-4 (DPP-4) inhibition coverage to the conventional twice-daily regimen.

Vildagliptin works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces fasting and post-meal sugar levels.

This diabetes drug has established its usefulness over the years by displaying significant HbA1c lowering accompanied by body weight-neutral and lipid-neutral effects, low risk of edema, and low risk of hypoglycemia. These characteristics make vildagliptin a favorable partner for combination therapy as well as newer formulations like a sustained release. Several studies have also focussed on establishing the safety parameters of Vildagliptin.

In this video, Prof. Dr Aravinda Jagadeesha, a diabetologist and the chairman at Dr Aravind's Diabetes Centre in Bengaluru, India talks about the safety and efficacy profile of Vildagliptin 100mg SR.

Vildagliptin is now present in different therapeutic doses and formulations which makes it compliant in treatment algorithms. Vildagliptin 100mg sustained release formulation, which is bioequivalent to Vildagliptin 50 mg BID, also displays similar efficacy and safety as the BID formulation.

Safety parameters of vildagliptin at all doses have been well-studied and well-documented, notes Dr Aravinda Jagadeesha.

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Dr. Nandita Mohan

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Safety and Efficacy of Vildagliptin 100mg SR- Ft. Prof. Dr Aravinda Jagadeesha

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