Taking This Obesity Medication with Menopause Hormone Therapy May Lead to More Effective Weight Loss: Study Suggests
Postmenopausal women with overweight or obesity experience significantly greater weight loss when treated with both tirzepatide and menopause hormone therapy (MHT), compared to tirzepatide alone. Findings were presented at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco.
Tirzepatide, a medication used to treat obesity, has shown promising results in various populations. However, weight gain associated with menopause often presents a unique challenge. Hormonal changes during menopause can lead to increased abdominal fat, reduced muscle mass, and altered energy metabolism factors that collectively elevate the risk of heart disease and other health concerns in millions of women.
"These data are the first to show the combined use of tirzepatide and menopause hormone therapy significantly increases treatment effectiveness in postmenopausal women," said Regina Castaneda, M.D., research fellow in the Division of Endocrinology at the Mayo Clinic in Jacksonville, Fla. "Previous studies of the medication semaglutide found similar results. Achieving these outcomes with a second obesity medication may indicate a broader efficacy trend for pairing these two classes of medications."
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