Lancet Commission Urges Global Action to Curb Rising Liver Cancer Burden by 2050

The Commission, comprised of experts across clinical medicine, public health, and policy, conducted a comprehensive review that involved literature analysis, evidence scoping, data synthesis, modeling, and real-world case studies. Their goal was to project the global trajectory of hepatocellular carcinoma through 2050 and establish measurable targets to mitigate its impact.

One of the key findings of the report is the need for an annual reduction of at least 2% in age-standardized liver cancer incidence rates to effectively curb the disease burden. Encouragingly, the report notes that “based on a conservative estimate, at least 60% of liver cancer is preventable via control of these risk factors,” particularly hepatitis B and C infections and alcohol use.

To achieve these goals, the Commission outlines ten evidence-based recommendations, centered on prevention, early detection, and treatment. These include scaling up viral hepatitis screening and treatment, reducing alcohol consumption through policy measures, and addressing environmental hazards like contaminated water. The report also highlights the rising threat of liver diseases such as MASLD and MASH, advocating for integrated strategies to combat them.

For improved outcomes, the authors stress enhanced surveillance in high-risk populations and equitable access to care, especially in low- and middle-income countries.

Reference: The Lancet Commission on addressing the global hepatocellular carcinoma burden: comprehensive strategies from prevention to treatment, Chan, Stephen Lam et al. The Lancet, Volume 0, Issue 0