Trial shows Combination Immunotherapy May be effective against Various Gastrointestinal Cancers
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A new form of tumor infiltrating lymphocyte therapy, a form of personalized cancer immunotherapy, improved the treatment's effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial published in Nature Medicine.
This therapy could be used to treat a variety of solid tumors, which has so far eluded researchers developing cell-based therapies.
This form of therapy involves identifying and selecting immune cells that are found in the tumor that specifically recognize and attack a patient’s tumor cells. Next, scientists grow those tumor infiltrating lymphocyte into large quantities in the laboratory before they are finally administered to the patient.
Patients in the clinical trial, who had a variety of gastrointestinal tumors, also received the immune checkpoint inhibitor pembrolizumab (Keytruda) to help further boost their immune response. The result was nearly 24% of patients treated with selected tumor infiltrating lymphocyte plus pembrolizumab had a substantial reduction in the size of their tumors, compared with 7.7% of patients who received selected tumor infiltrating lymphocyte without pembrolizumab. Patients treated with tumor infiltrating lymphocyte that had not been selected for anti-tumor activity had no tumor shrinkage.
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