Urea Cycle Defects Linked to Fatty Liver Disease? Study Sheds Light
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In a recent study published in Cell Metabolism, revealed a crucial connection between urea cycle defects-which are essential for ammonia detoxification in the body-and the onset of fatty liver disease.
Researchers discovered that defects in the urea cycle cause secondary disruptions in the tricarboxylic acid (TCA) cycle, an essential pathway for energy metabolism. This disruption leads to poor calorie use and excessive fat accumulation in the liver, which can result in inflammation and fibrosis, thereby advancing the progression of the disease.
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