Health Bulletin 5/November/2022

Here are the top health news for the day:

MCC adds 90 MBBS, 66 BSc Nursing seats to Round 2 NEET counselling, details

Through a recent notice, MCC (Medical Counseling Committee) has informed about the addition of 156 MBBS and Bsc Nursing seats in ROUnd 2 of NEET counselling 2022.

According to the notification, 90 MBBS and 66 BSc Nursing seats have been added to the round 2 seat matrix.

For more details, check out the link given below:

MCC Adds 90 MBBS, 66 BSc Nursing Seats To Round 2 NEET Counselling, Details

Patient carried dead foetus for week before dying herself: Odisha HC slams Govt, orders 10 lakh compensation, immediate action against doctors

Coming down strongly on doctors, health workers as well as the government in the case of the death of a female patient who was apprently carrying a dead foetus in her body for 5 days and later passed away, the Odisha High court has issued a series of directions in a medical negligence case.

The bench of Orissa High Court issued directions to the State Government to take strong action against the errant doctors, and provide compensation of Rs 10 lakhs to the family members of the deceased patient due to the negligent and careless attitude of the doctors and constitute schemes and policies for the pregnant women concerning the issue of maternal deaths.

For more details, check out the link given below:

Patient Carried Dead Foetus For Week Before Dying Herself: Odisha HC Slams Govt, Orders 10 Lakh Compensation, Immediate Action Against Doctors

Researchers provide insights on how to overcome resistance in cancer therapy

The latest developmental drugs, particularly for the use in oncology, rely on the targeted degradation of harmful pathogenic proteins. In a recent study, researchers at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, and the University of Dundee (UK) identify potential resistance mechanisms and provide insights on how to overcome them.

Traditional targeted cancer therapies mainly rely on drugs that bind pathogenic proteins and inhibit their function. The latest development of drugs has brought forward chemical molecules known as degraders, which force the targeted degradation of disease relevant proteins. This method of targeted protein degradation is not only more efficient, but also better at overcoming potential drug resistance. For many years, CeMM Principal Investigator Georg Winter and his research group have been working on further developing this paradigm. Small-molecule degraders work like a glue by recruiting the defective, disease-causing protein to effectors of the cellular waste disposal systems, which are known as E3 ubiquitin ligases. This binding in turn kick-starts the degradation process of the defective protein. Alexander Hanzl, first author and PhD student in the Winter Lab at CeMM, conducted a study to investigate which resistances can arise during the degradation process. He explains, "One challenge with degraders is that they have to bind two sites at once – both the defective protein and a protein of our cell's own degradation system, the E3 ligase. It is therefore all the more important to understand the process of binding and ubiquitination in functional detail. Only then can future degraders be modeled in the best possible way".

Reference:

Hanzl, A., Casement, R., Imrichova, H. et al. Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Nat Chem Biol (2022). https://doi.org/10.1038/s41589-022-01177-2