Stool-Based Molecular Test May Enhance TB Detection in Adults with HIV: Study Reveals
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A new study showed that the Xpert MTB/Ultra molecular diagnostic test for stool samples, until now recommended only for children, could be established as an additional test for diagnosing tuberculosis in adults living with HIV. The results, published in The Lancet Microbe, could represent a paradigm shift in the diagnosis of the disease in this population.
Researchers from the Stool4TB project proposed using a molecular test, currently used on respiratory samples, on stool samples. This test is already recommended for children because they have difficulty producing sputum. The research was conducted between December 2021 and August 2024 in medical centres in three African countries -Eswatini, Mozambique, and Uganda-, and recruited 677 patients over 15 years old with HIV and suspected TB. Participants provided sputum, urine, stool, and blood samples.
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