1/February/2022 Top Medical Bulletin

Here are todays top medical stories

Familial hypercholesterolemia to be treated efficiently with Inclisiran

The ORION- 4 trial in the Journal of the American College of Cardiology reveals that pooled safety and efficacy data of inclisiran, when given twice yearly in addition to maximally tolerated statin therapy with or without other LDL-Cholesterol lowering agents, is an effective, safe, and well-tolerated treatment to lower LDL-Cholesterol in adults with heterozygous familial hypercholesterolemia, atherosclerotic cardiovascular disease, or atherosclerotic cardiovascular disease risk equivalents.

Inclisiran is a popular drug used to treat high cholesterol. Familial hypercholesterolemia is a genetic disorder. It is caused by a defect on chromosome 19. The defect makes the body unable to remove low density lipoprotein LDL, or bad cholesterol from the blood.

Abnormal uterine bleeding by anticoagulation therapy treated by Uterine artery embolization

Approximations of 600,000 hysterectomies are performed annually in the United States. An estimated 20 million US women have had a hysterectomy; more than one-third of all women have had a hysterectomy by age of 60.

 Study reports uterine artery embolization was an effective tool in the management of anticoagulant associated abnormal uterine bleeding, resulting in decreased bleeding while allowing the continuation of anticoagulation therapy, with high rates of uterine preservation and preserved menses published in The Journal of Minimally Invasive Gynecology

Alcohol Consumption Raises Risk of Developing Hypertension in Men

Alcohol-related hypertension is a well-defined clinical entity with a comprehensive foundation based on a large number of cross-sectional and prospective epidemiological studies. In a study, researchers reiterated the association between alcohol intake and the risk of developing hypertension, especially in men.

The study findings were published in the journal Nutrition on July 22, 2021 aimed to find the effect of alcoholic-beverage consumption on blood pressure (BP) and incidence of hypertension, after a 4-y follow-up, in participants of the Longitudinal Adult Health Study (ELSA-Brasil).

Although previous studies have already confirmed the harmful effects of alcohol consumption on the cardiovascular system, especially by elevating BP levels, the strength of this relationship was not investigated in the Brazilian population.

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Alcohol Consumption Raises Risk of Developing Hypertension in Men

Addition of anacetrapib to statins lowers coronary events in Atherosclerotic cardiovascular disease: REVEAL trial

 A randomized controlled trial REVEAL that addition of cholesteryl ester transfer protein inhibitor therapy anacetrapib to intensive statin therapy lowers the risk of major coronary events in patients with atherosclerotic vascular disease. The study has been published in the European Heart Journal.

Based on the analysis, they found that with longer follow-up the beneficial effects of anacetrapib on major coronary events increased, and no adverse effects emerged on non-vascular mortality or morbidity. The findings suggest that trials of lipid-modifying agents should have the sufficiently long treatment and follow-up durations in order to fully assess the benefits and harms of treatment.

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Addition of anacetrapib to statins lowers coronary events in ASCVD: REVEAL trial 

Carbohydrate counting along with DASH diet beneficial in gestational diabetes

Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy that has significant impacts on both mother and her offspring health. Carbohydrate counting along with the DASH diet is beneficial in gestational diabetes, according to a recent study published in Clinical Nutrition.

The carbohydrate counting and the carbohydrate counting combined with DASH dietary interventions resulted in beneficial effects on FBG and 1 h PG compared with the control diet. The three dietary interventions produced similar maternal and neonatal outcomes in women with GDM.

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Carbohydrate counting along with DASH diet beneficial in gestational diabetes: Study