Medical Bulletin 04/November/2023

Investigators performed a meta-analysis of the RCTs evaluating SOC treatment with radiotherapy and androgen deprivation therapy or with radical prostatectomy versus SOC plus docetaxel. The final study cohort of 2,184 patients included 145 eligible patients (6.6%) across four eligible RCTs.

Reference: Mortality Risk for Docetaxel-Treated, High-Grade Prostate Cancer With Low PSA Levels

Higher risk of breast cancer in women with false-positive mammography result

Women who receive a false positive mammography result are more likely to develop breast cancer over the subsequent 20 years, report researchers from Karolinska Institute in a study published in JAMA Oncology. The risk is highest for women aged between 60 and 75 and who have low breast density.

At each screening visit, approximately three per cent of the women who undergo screening have a false positive result, which means that they are recalled for further examination without any cancer diagnosis. False-positive mammography results can cause psychological anxiety and influence screening attendance. Previous studies indicated that false-positive mammography results were associated with a short-term increased risk of breast cancer.

Reference: Breast cancer incidence after a false-positive mammography result, JAMA Oncology, DOI: 10.1001/jamaoncol.2023.4519