Medical Bulletin 2/January/2022

Here are the top medical news for the day:

DNA methylation-based measures of biological aging and cognitive decline

DNA methylation-based (DNAm) measures of biological aging associate with increased risk of morbidity and mortality, but their links with cognitive decline are less established.

In this new study, researchers Rebecca G. Reed, Judith E. Carroll, Anna L. Marsland, and Stephen B. Manuck from the University of Pittsburgh and the University of California examined changes over a 16-year interval in epigenetic clocks (the traditional and principal components [PC]-based Horvath, Hannum, PhenoAge, GrimAge) and pace of aging measures (Dunedin PoAm, Dunedin PACE) in 48 midlife adults enrolled in the longitudinal arm of the Adult Health and Behavior project (56% Female, baseline AgeM = 44.7 years), selected for discrepant cognitive trajectories.

Reference:

DNA methylation-based measures of biological aging and cognitive decline over 16-years: preliminary longitudinal findings in midlife,Aging-US,DOI: 10.18632/aging.204376

Study finds that delaying antibiotics for neutropenic fever may not affect survival of cancer inpatients

Neutropenia-low levels of white blood cells called neutrophils, which fight infection-develops in more than 80% of patients who receive chemotherapy for a blood cancer. It occurs because chemotherapy destroys neutrophils along with tumor cells.

In cancer patients with neutropenic fever, delaying antibiotic treatment past 60 minutes from the time of fever detection does not reduce the short-term chance of survival, according to a study in the American Journal of Medical Quality. The journal is published in the Lippincott portfolio by Wolters Kluwer.

Reference:

Adam Binder et al,JOURNAL American Journal of Medical Quality

Success rate of mini-implants in adult patients undergoing orthodontic treatment

One of the major things in dental care is anchorage control during tooth movement for ensuring successful orthodontic treatment.

A recent study in Asian Pacific Orthodontic Scoiety Trends in Orthodontics published in scentific scholar, (scientific scholar) involved analysis of 52 recently published articles that were extracted for qualitative synthesis among which 24 articles were reviewed for meta-analysis.

Reference:

Devadkar RS, Potnis S, Toshniwal N, Pharande S, Vinay V. Success rate of mini-implants based on side of insertion and type of jaw in adult patients undergoing orthodontic treatment - A systematic review and meta-analysis. APOS Trends Ortho 2022;12:295-305.