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Here are the top medical news for the news:
Revolutionary 3D treatment for diabetes
Researchers at Queen's University Belfast have designed a new bandage treatment, known as a scaffold, to treat diabetic foot ulcers, which is cost-effective while improving patient outcomes.
Produced by 3D bioprinting, the scaffolds slowly release antibiotics over a four-week period to effectively treat the wound.
Diabetes, a lifelong condition that causes a person's blood sugar level to become too high, is among the top ten causes of deaths worldwide.
Diabetic foot ulcer (DFU), is a serious complication of diabetes, affecting approximately 25% of diabetic patients. When identified, over 50% are already infected and over 70% of cases result in lower limb amputation.
Reference:
Ms Katie Glover et al,Drug Delivery and Translational Research
Cavity-causing microbes can form crawling superorganisms
A cross-kingdom partnership between bacteria and fungi can result in the two joining to form a "superorganism" with unusual strength and resilience. Found in the saliva of toddlers with severe childhood tooth decay, these assemblages can effectively colonize teeth. They were stickier, more resistant to antimicrobials, and more difficult to remove from teeth than either the bacteria or the fungi alone, according to the research team, led by University of Pennsylvania School of Dental Medicine scientists.
What's more, the assemblages unexpectedly sprout "limbs" that propel them to "walk" and "leap" to quickly spread on the tooth surface, despite each microbe on its own being non-motile.
Reference:
Anand Swaroop et al, High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci, Nature Communications, DOI: 10.1038/s41467-022-33427-1
Alzheimer's disease detection in the blood
A team of scientists from Hokkaido University and Toppan, have developed a biosensing technology that can detect Aβ-binding exosomes in the blood of mice, which increase as Aβ accumulates in the brain.
When tested on mice models, the Aβ-binding exosome Digital ICATM (idICA) showed that the concentration of Aβ-binding exosomes increased with the increase in age of the mice.
Reference:
Kohei Yuyama et al, Immuno-digital invasive cleavage assay for analyzing Alzheimer's amyloid β-bound extracellular vesicles, Alzheimer s Research and Therapy, DOI: 10.1186/s13195-022- 01073-w
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