Cancer cells produce small amounts of their own form of collagen, creating a unique extracellular matrix that affects the tumor microbiome and protects against immune responses, according to a new study by researchers. This abnormal collagen structure is fundamentally different from normal collagen made in the human body, providing a highly specific target for therapeutic strategies.
This study, published in Cancer Cell, builds upon previously published findings from the chair of Cancer Biology to bring a new understanding of the unique roles of collagen made by fibroblasts and by cancer cells.
Reference: "Cancer cells make a unique form of collagen, protecting them from immune response"; Cancer Cell.
2. Trauma of diagnosis stays with eye disease patients
A research team interviewed patients of a range of ages who had been diagnosed with eye disease in England over the course of several decades and assessed the psychological impact of the way their diagnosis was communicated. The study is published in BMJ Journal.
A world-first study by Monash University, in Melbourne, Australia have discovered a pathway to the regeneration of insulin in pancreatic stem cells, a major breakthrough toward new therapies to treat Type 1 and Type 2 diabetes.
Using the pancreas stem cells of type 1 diabetic donors, researchers were able to effectively reactivate them to become insulin-expressing and functionally resemble beta-like cells through the use of a drug approved by the US Food and Drug Administration but not currently licensed for diabetes treatment.
Reference: Nature journal, Signal Transduction and Targeted Therapy titled: Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor; DOI: 10.1038/s41392-022-01034-7.
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