Breakthrough obesity drug may allow unlimited eating without weight gain

Researchers led by Director C. Justin LEE from the Center for Cognition and Sociality (CCS) within the Institute for Basic Science (IBS) have discovered new insights into the regulation of fat metabolism. The focus of their study lies within the star-shaped non-neuronal cells in the brain, known as 'astrocytes'. Furthermore, the group announced successful animal experiments using the newly developed drug 'KDS2010', which allowed the mice to successfully achieve weight loss without resorting to dietary restrictions.

Reference: "Hypothalamic GABRA5-positive Neurons Control Obesity via Astrocytic GABA" is published in the journal Nature Metabolism, August 31, 2023. DOI: 10.1038/s42255-023-00877-w