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COVID-19 antibody treatments aren't as effective for new variants

Written By :  Dr. Nandita Mohan
Medically Reviewed By :  Dr. Kamal Kant Kohli
Published On 2022-06-11 04:30 GMT   |   Update On 2022-06-11 04:30 GMT
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The study published in Biochemistry journal is the first to explore the effects of multiple mutations in the evolution of SARS-CoV-2 variants. The findings can help scientists better understand the properties of current and new variants.

Nearly half of 4.3 million variant sequences that contain any of these three mutations have all three occurring together. Although individual mutations have both beneficial and deleterious effects, when they come together, these effects get cancelled out, leading to improved selection of the mutations together.

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The researchers found the three mutations performed very distinct and specific roles that contributed toward improving the virus fitness and build the case for their positive selection, even though individual mutations have deleterious effects that make them prone to negative selection. When these mutations come together, the deleterious effects are mitigated due to the presence of compensatory effects.

Hence, the authors concluded that the collective effect of these mutations is far more advantageous for virus fitness than the individual mutations and the presence of multiple mutations improves the selection of individual mutations.

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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