Dolo 650: Popular Painkiller or Silent Liver Threat? Study Sheds Light
Dolo 650, a popular paracetamol brand, is commonly used to treat pain and fever in India. While it's generally safe when taken properly, overuse, especially without medical guidance, can harm the liver and kidneys. Paracetamol overdose is a leading cause of acute liver failure globally, with major medical journals warning that it accounts for more than half of liver failure cases in some countries.
“If you’ve ever had a fever in India, chances are someone handed you a strip of Dolo 650 without blinking,” says Dr. Naveen Polavarapu, a senior gastroenterologist. Its widespread use, particularly during the COVID-19 pandemic, has led to growing concerns among doctors about misuse.
Dr. Polavarapu explains, “Paracetamol is processed by the liver. In normal doses, it’s safe. But when taken in excess, it can lead to liver damage as it depletes an enzyme called glutathione, leading to toxic buildup.”
Excessive doses can lead to acute liver failure. “Anything over 8 grams a day—around 15 to 20 tablets of 650 mg is potentially lethal,” he warns. The safe dose for an average adult is 4 grams per day.
“People often take Dolo 650 for pain relief without understanding the risks,” Dr. Polavarapu adds. While fatty liver is indirectly linked to repeated paracetamol use, it’s important to avoid overuse of painkillers like Dolo 650, which can harm the liver over time.
Dr. T. Ravi Raju, a nephrologist, reassures, “Paracetamol doesn’t typically cause kidney damage unless combined with NSAIDs over long periods.”
Experts agree that while Dolo 650 is effective, it should be taken responsibly to avoid serious health risks.
References: Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013;369:2525–2534. doi: 10.1056/NEJMra1208937. [DOI] [PubMed] [Google Scholar]
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