How oral drugs absorption by stomach is affected by body posture
Written By : Isra Zaman
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-08-12 04:30 GMT | Update On 2022-08-12 04:30 GMT
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Researchers from Johns Hopkins University and Johns Hopkins School of Medicine employed a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach-a "StomachSim"-to investigate and quantify the effect of the body posture and stomach motility on drug bioavailability.
Stomach contents, motility, and gastric fluid dynamics all play a role in a drug's bioavailability, and stomach contractions can induce pressure and generate complex pill trajectories. This results in varying rates of pill dissolution and nonuniform emptying of the drug into the duodenum and, sometimes, gastric dumping in the case of modified-release dosage.
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