Impaired ketogenesis which ties metabolism to T cell dysfunction in COVID-19
At least that is what the results of the current study suggest. "We found that patients with influenza infections produce ketone bodies in considerable quantities," explains Prof. Dr. Christoph Wilhelm from the Institute of Clinical Chemistry and Clinical Pharmacology at the University Hospital Bonn, who is also a member of the Immunosensation2 Cluster of Excellence at the University of Bonn. "In contrast, we saw hardly any increase in Covid-19 patients, at least in those with a moderate or severe course."
In addition, it was striking that those infected with the coronavirus had lower levels of inflammatory messengers in their blood. This was particularly true for interferon-gamma.
The researchers also saw similar effects in another important group of immune cells, the killer T cells. Apparently, the ketone bodies promote the function of mitochondria, metabolic powerhouses fueling the immune cells. This not only ensures improved energy production but also provides molecules that are needed for interferon production.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.