Leptospirosis in central & eastern Uttar Pradesh, an underreported disease
Written By : Dr. Nandita Mohan
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-08-29 03:30 GMT | Update On 2022-08-29 07:46 GMT
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Only a few studies are available which report the prevalence of leptospirosis in this State. Hence, this study was undertaken to know the status of the disease in central and eastern Uttar Pradesh.
A total of 143 serum and urine samples were collected from patients with acute febrile illness. All the serum samples were tested for Leptospira by rapid IgM antibody card and IgM ELISA and urine samples were tested by real-time polymerase chain reaction (RT-PCR) to detect Leptospira DNA. All positive and 10 per cent negative sera from ELISA and RT-PCR were sent to the ICMR-Regional Medical Research Centre, Port Blair for microscopic agglutination test.
Thirty eight i.e 26.6% out of 143 samples were positive for leptospirosis either by ELISA or RT-PCR. Positive results were 6% by Rapid card, 22% by IgM ELISA, 7% by microscopic agglutination test 7% by RT-PCR.
So In conclusion, leptospirosis was found to be one of the important causes for acute febrile illness in the central and eastern parts of Uttar Pradesh. The results of the present study suggest that it is necessary to increase diagnostic facility and awareness in clinicians for the screening of leptospirosis in acutely febrile patients to decrease morbidity and mortality associated with this disease.
Reference: Shukla S, Mittal V, Karoli R, Singh P, Singh A. Leptospirosis in central & eastern Uttar Pradesh, an underreported disease: A prospective cross-sectional study. Indian J Med Res. 2022 Jun 1. doi: 10.4103/ijmr.IJMR_1811_19. Epub ahead of print. PMID: 35647944.
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