Low Vitamin D levels associated with worse cognitive function in multiple sclerosis

Low serum 25-OH-vitamin D associated with worse cognitive function in multiple sclerosis suggests a new study published in the Multiple Sclerosis and related disorders.

Cognitive impairment frequently affects people with multiple sclerosis (MS). Low vitamin D has been associated with cognitive dysfunction in different neurodegenerative diseases, and, in MS, with motor disability and disease activity. We aim to investigate associations between vitamin D and cognitive status in MS.

In this cross-sectional study, we included 181 MS patients, recruited consecutively at the MS Unit of the Policlinico Federico II University Hospital of Naples, Italy, between January and April 2022, with serum 25 hydroxy (25-OH) vitamin D measurements using Chemiluminescence-ImmunoAssay, and cognitive assessment using the Brief International Cognitive Assessment for MS (BICAMS), which includes Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-II (CVLT-II) and Brief Visuospatial Memory Test-Revised (BVMT-R).

Lower serum 25-OH-vitamin D was associated with worse cognitive function in MS. Future studies should consider longitudinal variations in cognitive function in relation to vitamin D supplementation.

Reference: Antonio Luca Spiezia, Fabrizia Falco, Andrea Manganelli, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia.Low serum 25 hydroxy-vitamin D levels are associated with cognitive impairment in multiple sclerosis. Open AccessPublished:September 30, 2023DOI:https://doi.org/10.1016/j.msard.2023.105044