New nasal vaccine strategy could improve COVID-19 protection

Written By :  Dr. Nandita Mohan
Medically Reviewed By :  Dr. Kamal Kant Kohli
Published On 2022-11-17 03:30 GMT   |   Update On 2024-02-15 06:25 GMT
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Currently many vaccines against SARS-CoV-2 have substantially been found to reduce mortality and severe progression of the disease, but protection against infection is less effective. Vaccinated individuals are still catching COVID-19 and can spread the infection, so breakthrough infections are still occurring.

Researchers from the Centenary Institute and the University of Sydney have developed a new nasal vaccination strategy that induces potent lung immunity and protection against the SARS-CoV-2 coronavirus.

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The new vaccine approach has been tested successfully in mice and has the potential to be a powerful tool for enhancing protection against COVID-19 infection and minimising ongoing viral spread. Made up of the SARS-CoV-2 spike protein and an adjuvant called Pam2Cys (a molecule that helps stimulate a stronger immune response in the body.

This vaccine differs from most current COVID-19 vaccines in that it enables generation of an immune response directly in those areas of the body that are likely to be the first point of contact for the virus - the nose, airway and lungs. This may help explain the vaccine's effectiveness.

Reference:

Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice. DOI:https://www.nature.com/articles/s41467-022-34297-3.

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Article Source : Nature Communications

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