New research finds immune inflammatory response not the cause of long COVID
Long Covid is not caused by an immune-inflammatory reaction to COVID-19, University of Bristol-led research finds. Emerging data demonstrate that immune activation may persist for months after COVID-19. To investigate this, the Bristol team collected and analyzed immune responses in blood samples from 63 patients hospitalized with mild, moderate or severe COVID-19 at the start of the pandemic and before vaccines were available.
The team found patients’ immune responses at three months with severe symptoms displayed significant dysfunction in their T-cell profiles indicating that inflammation may persist for months even after they have recovered from the virus. Reassuringly, results showed that even in severe cases inflammation in these patients resolved in time. At 12 months, both the immune profiles and inflammatory levels of patients with severe disease were similar to those of mild and moderate patients.
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