New Study Reveals How Saliva Activates Coagulation in Hemophilia A Patients
A recent study provides insights into the mechanisms of coagulation in persons with haemophilia A. The research team was able to show that saliva contains special vesicles that trigger rapid coagulation of the blood of haemophilic patients. The results were published in the scientific journal Blood.
The researchers studied the importance of the body's own fluids for blood coagulation, which had been forgotten for decades. The researchers discovered that the saliva of haemophilia A patients contains extrinsic tenase complexes, which are located on vesicles.
Extrinsic tenase complexes are protein complexes that consist of two coagulation factors (tissue factor TF and factor VIIa) and initiate the activation of the coagulation cascade when they come into contact with blood.
Analyses by the study authors confirm that mucosal bleeding in the mouth of these patients is indeed rare and stops quickly.
The scientists were able to prove that the coagulation-promoting properties of maternal milk, amniotic fluid, urine -- and now also saliva -- are due to the presence of extracellular vesicles with extrinsic tenase complexes.
The results provide important insights into the mechanisms of coagulation and contribute to a better understanding of haemophilia A.
Reference: https://www.meduniwien.ac.at/web/en/ueber-uns/news/2025/news-in-january-2025/saliva-activates-coagulation-in-persons-with-haemophilia-a/
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