Oral immunotherapy effective in controlling peanut allergy
The IMPACT trial, published in The Lancet journal has found that giving peanut oral immunotherapy to highly peanut-allergic children ages 1 to 3 years safely desensitized most of them to peanut and induced remission of peanut allergy. Peanut allergy affects about 2% of children in the United States, or nearly 1.5 million individuals ages 17 years and younger.
The immunotherapy consisted of a daily oral dose of peanut flour for 2.5 years. Remission was defined as being able to eat 5 grams of peanut protein, equivalent to 1.5 tablespoons of peanut butter, without having an allergic reaction six months after completing immunotherapy. The youngest children and those who started the trial with lower levels of peanut-specific antibodies were most likely to achieve remission.
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