Promising Results of Triple Antibody Therapy For Long-Term HIV Control: Randomized Trial Finds
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In a study of 12 participants, researchers at Beth Israel Deaconess Medical Center (BIDMC) have demonstrated that a cocktail of three broadly neutralizing antibodies (bNAb) successfully suppressed the virus in people living with HIV.
A subset of participants also demonstrated long-term control of the virus months after antibody levels declined to low or undetectable. The findings were published in Nature Medicine.
“Our data suggest that the triple broadly neutralizing antibodies (bNAb) cocktail can lead to virologic control for a prolonged period of time in most people living with HIV following ART discontinuation,” said co-corresponding author Dan H. Barouch, MD, PhD, director of the Center for Virology and Vaccine Research at BIDMC. “Larger studies are planned based on these results.”
HIV remains a global public health challenge. While ART a combination of drugs typically taken daily has transformed HIV from a fatal illness into a manageable long-term condition, it does not eliminate the virus. The antibody cocktail tested in this study could offer an alternative that reduces reliance on daily medication.
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