Revolutionary Needle-Free Intranasal COVID-19 Vaccine: Study
A recent paper published in Nature Communications reveals the efficacy of delivering a COVID-19 vaccine via the nasal passages.
These vaccines are live attenuated intranasal vaccines, called CDO-7N-1 which are delivered through intranasal passages that induce robust mucosal and systemic neutralizing antibody and T-cell subset responses when tested in mice which were triggered by a single immunization.
The virus that causes COVID-19, known as SARS-CoV-2, has led to more than 700 million infections and 7 million deaths around the world so far. It still poses a serious threat to vulnerable people.
Most current vaccines are made to target the spike protein of the SARS-CoV-2 virus, specifically the part of this protein that most antibodies attack. These vaccines worked well against earlier virus variants like alpha, beta, gamma, and delta. However, their effectiveness in preventing symptoms has dropped significantly with the arrival of new variants that have changes in the spike protein.
Live-attenuated vaccines (LAVs) have several key benefits compared to other types of vaccines. They produce strong and lasting immune responses, often with just one dose. Because live-attenuated vaccines contain the entire virus, they trigger a broad immune response, unlike vaccines that use only a single antigen (such as the spike protein) which targets a narrower range.
The vaccine has been licensed to Indian Immunologicals Ltd, a major vaccine manufacturer.
Reference: Liu, X., Ng, W.H., Zusinaite, E. et al. A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants. Nat Commun 15, 7225 (2024). https://doi.org/10.1038/s41467-024-51535-y
Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.