Severe form of mpox with high mortality seen in people with advanced HIV, finds study
An international collaboration of clinicians published the largest case series of mpox infection in people with advanced HIV disease in The Lancet, in which they identify a new severe form of mpox. The majority of mpox infections in the current multi-country outbreak have occurred in sexual networks of gay, bisexual and other men who have sex with men.
The SHARE-net clinicians looked at 382 people with advanced HIV disease and mpox, including 27 of the 60 people reported to have died of mpox during the multi-country outbreak. The group describes a very severe form of mpox characterised by widespread, large, necrotising skin lesions; high rates of severe infections; and, in some cases, unusual lung lesions. This form of the disease carries a 15% mortality in people with advanced HIV disease and immunosuppression. All 27 deaths occurred within this group.
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