Study Sheds Light on Role of Sex Hormones in Weight Gain and Cardiometabolic Health
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A decrease in estrogen during menopause leads to alterations in body fat distribution and an increased risk of cardiovascular and metabolic diseases. However, a recent study has uncovered potential treatments that could eventually reverse these adverse changes.
A study published in Nature Communications suggests that blocking a receptor known as Cxcr4 in mice decreases the likelihood of fat stem cells becoming white fat, or white adipose tissue. This approach could be used alongside low doses of estrogen therapy to help manage changes in body fat distribution in menopausal women and reduce the risk of cardiometabolic diseases. Typically, effective estrogen therapy requires higher doses, which increases the risk of breast cancer.
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