Acute Kidney Injury in 25% of patients on ICI therapy: Yale Study

The study suggests several possible causes of Acute Kidney Injuries which could be: Immune-related adverse events which are off-target effects of T-cell activation against non-tumor cells that cause damage to various organs including the kidney. Or Prerenal azotemia and acute tubular injury (ATI)

It may also result from Coadministered drugs like chemotherapy and vascular endothelial growth factor-pathway targeting drugs. Or Morbidity related to malignancy itself, such as postrenal obstruction from the tumor, kidney involvement by tumor, and coagulopathy.