Genes may affect survival in Parkinson's patients
Scientists from different institutes studied the records of 2,037 Parkinson's disease patients from their first hospital visit and believed that the genetic variants may shed light in how fast or slow Parkinson's disease progresses in cases where a single gene is involved.
Patients who had either the LRRK2 or PRKN gene mutations had a longer survival time than patients without a gene mutation. Conversely, those who had the SNCA or GBA mutations had a shorter survival time than those without a mutation.
Monogenic forms of Parkinson's disease – those caused by a single gene variant – account for approximately 5% of all cases, as most appear to occur sporadically, without any family history. It was found that a change in the LRRK2 gene is probably the most common genetic variant associated with Parkinson's disease. People who carry this variant may develop the disease later in life and have a 70% chance of being diagnosed by age of 80.
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